I saw Jahn present this work last week - I don't think I've ever seen such a comprehensive analysis of any biological system. One thing that stuck in my mind is him casually flashing up a slide showing ~80 quantitative Western blots, all of which had been optimised and analysed by his post-doc Takamori (the first author on this paper). When he reached the 3D model of the vesicle and started rotating it on-screen there was an audible gasp from the audience. This is truly inspiring science.

Yes. When I read it I remember thinking how fortunate for neuroscience that these competent molecular biologists have chosen the synaptic vesicle as the model vesicle.